Aggregated polyglutamine peptides delivered to nuclei are toxic to mammalian cells
نویسندگان
چکیده
منابع مشابه
Aggregated polyglutamine peptides delivered to nuclei are toxic to mammalian cells.
A number of observations point to the aggregation of expanded polyglutamine [poly(Q)]-containing proteins as playing a central role in the etiology of Huntington's disease (HD) and other expanded CAG-repeat diseases. Transfected cell and transgenic animal models provide some of this support, but irrefutable data on the cytotoxicity of poly(Q) aggregates is lacking. This may be due in part to di...
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ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 2002
ISSN: 1460-2083
DOI: 10.1093/hmg/11.23.2905